MRFF Funding Opportunities

Several funding opportunities are currently available under the MRFF, seeking to address a range of different diseases and issues in different health settings. They are presented in order of application closing date below.

Want to assist with assessing MRFF grants?
The Department of Health is currently seeking interest from a range of stakeholders to assist in MRFF grant review and assessment as a member of a Grant Assessment Committee. More information is available here.

Open for application now

Multiple Sclerosis

$18 million is available for research projects that:

Stream 1: promote Australian involvement in international collaborative investigator-initiated clinical trials testing the effectiveness of vaccines for prevention of latent Epstein-Barr virus infection through the establishment and coordination of clinical trials site/s in Australia

Stream 2: clinical trials to accelerate the development or repurposing of therapeutic candidates (including antivirals) to treat Epstein-Barr virus for the purpose of preventing or treating conditions such as multiple sclerosis

Stream 3: characterise how immune responses to viral infections trigger autoimmune diseases including multiple sclerosis in some individuals to generate knowledge that supports risk stratification so identified individuals can employ strategies to reduce their chance of developing autoimmune disease

Stream 4: develop, implement and/or validate approaches for early intervention in individuals recovering from viral infections that aim to reduce the risk and/or severity of the long-term autoimmune consequences, including multiple sclerosis.

This grant opportunity is being administered by the NHMRC over two rounds and minimum data is due on:

Stream 3 and 4: 16 November 2022 CLOSED

Stream 1 and 2: 25 January 2023

Grant guidelines are available here.

2022 Genomics Health Futures Mission

$66 million is available for medical research and medical innovation projects that:

    • Stream 1 (Targeted Call for Research): identify and diagnose novel – primarily monogenic or oligogenic – rare diseases and increase the genomic diagnostic rate towards 70% by 2025.
    • Stream 2 (Targeted Call for Research): conduct research to develop pharmacogenomic approaches to enhance medication efficacy and reduce harm by preventing adverse side effects.
    • Stream 3 (Targeted Call for Research): conduct research to identify novel methods for progressing the application of polygenic scores in Australian health care.
    • Stream 4 (Targeted Call for Research): conduct education and/or implementation research on strategies for improving clinical capacity to apply genomics in the primary health care sector.
    • Stream 5 (Targeted Call for Research): conduct implementation research addressing inequalities of access and increasing the quality of clinical genetics services for Aboriginal and/or Torres Strait Islander people.

The maximum grant is $3 million. This grant opportunity is being administered by the NHMRC and minimum data is due on 1 February.

2022 Assessment of High Cost Gene Treatments and Digital Health Interventions

$10 million is available to support medical research and medical innovation projects that:

    • Stream 1 (Targeted Call for Research (TCR):  develop a generalisable model to support assessment and validation of the clinical effectiveness and cost-effectiveness of new and emerging high upfront-cost therapeutics which includes consideration of ethical, legal, social and cultural aspects.
    • Stream 2 (TCR): conduct an implementation trial in both rural/remote and major city settings utilising the continuous remote monitoring capabilities of pacemakers and implantable cardioverter defibrillators to assess their health and non-health outcomes such as patient preferences, usability and cost effectiveness and appropriateness.
    • Stream 3 (TCR): undertake a retrospective or prospective evaluation of an implementation of a digital health intervention in order to assess the relative impact of augmenting face-to-face care with data from digital tools that advances assessment methods for digital innovations.

The maximum grant is $1.5 million. This grant opportunity is being administered by the NHMRC and minimum data is due on 31 January.

2022 International Clinical Trial Collaborations Grant Opportunity

A total of $12 million is available, with maximum grants of $3 million, over two separate rounds. Applications to this Grant Opportunity must propose a single clinical trial in Australia in collaboration with international counterparts which aims to:

    • give patients across Australia more access to clinical trials
    • show which treatments and medicines work best for patients
    • provide researchers with more opportunities to work with international colleagues to bring international trials to Australian patients
    • promote new approaches that support efficient and effective research.

This grant opportunity is being administered by the NHMRC over two rounds and minimum data is due on:

Round 1: 20 July 2022 CLOSED

Round 2:  8 February 2023

Grant guidelines are available here.

2022 Indigenous Health Research

$27.8 million is available, with individual grants of up to $3 million, for  research that addresses one of six Streams of research. The Streams address specific areas, including maternal health, mental health and multimorbidity.

Streams 1, 2, 3, and 6 are intended to support early stage, small scale research projects that seek to assess the potential and feasibility of novel strategies to address critical or intractable health issues. in specific areas, including Streams 4 and 5 are intended to support projects that progress research that addresses a specific health need.

This grant opportunity is being administered by the NHMRC and minimum data is due on 8 February. Grant guidelines are available here.

2022 Research Data Infrastructure

$10 million is available, with individual grants of up to $2.5 million, to fund the creation or extension of national research data infrastructure.

Projects should incorporate:

    • new linkage and/or use of data from at least 2 existing research data infrastructure sources of different types (e.g. administrative and biobank data, registry and biobank data, wearables and use artificial intelligence); and/or
    • novel methodologies and approaches that leverage and enhance existing linked research data infrastructure of at least 2 different types
    • a clear outline of how the proposed project will produce knowledge and outcomes that address an area of unmet medical need.

More information is available at Grant Connect here.

Applications close on 13 February. To apply, go to: business.gov.au/2022-rdi

2022 MRFF Joint Transnational Call

The European Joint Programme on Rare Diseases (EJP RD) brings over 130 institutions from 35 countries together to create a comprehensive, sustainable ecosystem allowing a virtuous circle between research, care and medical innovation. 

As part of the EJP RD, international organisations have joined forces to carry out a joint call for proposals for transnational cooperative research projects in the field of rare diseases. The list of participating funding organisations is listed on the EJP RD website. 

The joint call is published at the same time by the funding organisations in the respective countries and coordinated centrally by a Joint Call Secretariat (JCS). The JCS is based at the Institute of Health Carlos III (ISCIII, Spain). The respective national guidelines apply to the actual implementation of the national sub-projects. 

Applications are administered by the NHMRC and more information is available here. The maximum grant is $300,000 with funding expected to be available from June 2023. Applications close on 15 February.

Million Minds 2022

$8 million in total is available for research under two incubator streams:

  • Stream 1 (Incubator): conduct small-scale developmental projects to improve the understanding of:
    • Topic A: social determinants of mental health to inform the prevention of, and treatments for, mental illness and psychological distress
    • Topic B: social determinants and protective factors for the optimal mental health of children (0 to 12 years)
    • Topic C: social determinants and protective factors for the optimal mental health of young people (12 to 25 years)
  • Stream 2 (Incubator): conduct small-scale projects to develop new and improved diagnostic tools for mental illness.

Up to $1 million is available for each grant, with a duration of two years.

This grant opportunity is being administered by the NHMRC and minimum data is due on 1 March.

2022 Clinical Trials Opportunity

A total of $65 million is available for clinical trials with a maximum of $4 million per grant in the following four streams:

Rare Cancers, Rare Diseases and Unmet Need

    • Stream 1 – conduct a clinical trial of one or more treatments and/or management-based interventions for rare cancers, rare diseases and/or unmet need.
    • Stream 2 – conduct an implementation science trial to determine the best strategies for reducing inappropriate antibiotic use in clinical settings.

Effective health interventions

    • Stream 3 – conduct a clinical trial that reduces inequities in health outcomes by addressing the specific health and health care needs that are of priority for people in regional, rural, and remote communities.
    • Stream 4 – conduct a clinical trial that assesses the comparative effectiveness of two or more health interventions to treat a specific clinical condition, to inform the decisions of policy makers, clinicians, and consumers regarding healthcare and to minimise the use of unnecessary, ineffective, and harmful health interventions.

This grant opportunity is being administered by the NHMRC and minimum data is due on 3 May 2023.

2022 Rapid Applied Research Translation Grant Opportunity 

$38.5 million is available for research projects that encourage academic researchers and health service providers to collaborate to improve health care delivery, services and systems sustainability.

Three streams of funding will be available under this opportunity:

    • Streams 1 and 2 (Accelerator): rapid translation of research evidence into clinical practice
    • Stream 3 (Targeted Call for Research): adoption of evidence-based practice into health care.

The grant opportunity is administered by the Business Grants Hub and applications close on 12 May. More information is available here.

Upcoming opportunities

MRFF Frontiers

The next round of Frontiers Health and Medical Research will open on 13 February 2023.

This grant opportunity offers funding to support medical research and medical innovation programs of research that deliver a ‘moonshot’ by creating a treatment for a currently serious and incurable health condition, through a series of linked projects. The program of research can propose to develop novel health technologies and/or re-purpose existing health technologies in a novel way.

The process to get funding has 2 stages:

    • expression of interest – outlining a proposed program of research with a 10-year time horizon
    • full application, for a project of up to 5 years under the program of research.

Full applications may be submitted by invitation only. Applicants may propose to start research at any stage in the research pipeline from proof-of-concept, with the intention of achieving full implementation of the proposed technology in 10 years.

The program is administered by Business Grants Hub. More information is available here